Alle Publikationen

• Contemporaneous 3D characterization of acute and chronic myocardial I/R injury and response.
  Merz SF, Korste S, Bornemann L, Michel L, Stock P, Squire A, Soun C, Engel DR, Detzer J, Lörchner H, Hermann DM, Kamler M, Klode J, Hendgen-Cotta UB, Rassaf T, Gunzer M, Totzeck M.

  Nat Comm.
  Nature Communications, Volume 10, Article number: 2312 (2019)

  
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• Non-classical monocyte homing to the gut via α4β7 integrin mediates macrophage-dependent intestinal wound healing.
  Schleier L, Wiendl M, Heidbreder K, Binder MT, Atreya R, Rath T, Becker E, Schulz-Kuhnt A, Stahl A, Schulze LL, Ullrich K, Merz SF, Bornemann L, Gunzer M, Watson AJM, Neufert C, Atreya I, Neurath MF, Zundler S.

  Gut.
  Gut. 2019 May 15. pii: gutjnl-2018-316772. doi: 10.1136/gutjnl-2018-316772

  
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• Location of Neutrophils in Different Compartments of the Damaged Mouse Brain After Severe Ischemia/Reperfusion.
  Otxoa-de-Amezaga A, Gallizioli M, Pedragosa J, Justicia C, Miró-Mur F, Salas-Perdomo A, Díaz-Marugan L, Gunzer M, Planas AM.

  Stroke.
  Stroke. 2019 May 14:STROKEAHA118023837. doi: 10.1161/STROKEAHA.118.023837.

  
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• Externalized histone H4 orchestrates chronic inflammation by inducing lytic cell death.
  Silvestre-Roig C, Braster Q, Wichapong K, Lee EY, Teulon JM, Berrebeh N, Winter J, Adrover JM, Santos GS, Froese A, Lemnitzer P, Ortega-Gómez A, Chevre R, Marschner J, Schumski A, Winter C, Perez-Olivares L, Pan C, Paulin N, Schoufour T, Hartwig H, González-Ramos S, Kamp F, Megens RTA, Mowen KA, Gunzer M, Maegdefessel L, Hackeng T, Lutgens E, Daemen M, von Blume J, Anders HJ, Nikolaev VO, Pellequer JL, Weber C, Hidalgo A, Nicolaes GAF, Wong GCL, Soehnlein O.

  Nature.
  Nature. 2019 May;569(7755):236-240. doi: 10.1038/s41586-019-1167-6. Epub 2019 May 1.

  
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• Polymorphonuclear Neutrophils Play a Decisive Role for Brain Injury and Neurological Recovery Poststroke.
  Hermann DM, Gunzer M.

  Stroke
  Stroke. 2019 Mar;50(3):e40-e41. doi: 10.1161/STROKEAHA.118.021564.

  
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• Infection of B Cell Follicle-Resident Cells by Friend Retrovirus Occurs during Acute Infection and Is Maintained during Viral Persistence.
  Windmann S, Otto L, Hrycak CP, Malyshkina A, Bongard N, David P, Gunzer M, Dittmer U, Bayer W.

  MBio.
  MBio. 2019 Feb 19;10(1). pii: e00004-19. doi: 10.1128/mBio.00004-19.

  
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• Differential attenuation of β2 integrin-dependent and -independent neutrophil migration by Ly6G ligation.
  Cunin P, Lee PY, Kim E, Schmider AB, Cloutier N, Pare A, Gunzer M, Soberman RJ, Lacroix S, Boilard E, Lefort CT, Nigrovic PA.

  Blood Adv.
  Blood Adv. 2019 Feb 12;3(3):256-267. doi: 10.1182/bloodadvances.2018026732.

  
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• A network of trans-cortical capillaries as mainstay for blood circulation in long bones.
  Grüneboom A, Hawwari I, Weidner D, Culemann S, Müller S, Henneberg S, Brenzel A, Merz S, Bornemann L, Zec K, Wuelling M, Kling L, Hasenberg M, Voortmann S, Lang S, Baum W, Ohs A, Kraff O, Quick HH, Jäger M, Landgraeber S, Dudda M, Danuser R, Stein JV, Rohde M, Gelse K, Garbe AI, Adamczyk A, Westendorf AM, Hoffmann D, Christiansen S, Engel DR, Vortkamp A, Krönke G, Herrmann M, Kamradt T, Schett G, Hasenberg A, Gunzer M

  Nature Metabolism.
  

  
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• Cell-Type-Specific Responses to Interleukin-1 Control Microbial Invasion and Tumor-Elicited Inflammation in Colorectal Cancer.
  Dmitrieva-Posocco O, Dzutsev A, Posocco DF, Hou V, Yuan W, Thovarai V, Mufazalov IA, Gunzer M, Shilovskiy IP, Khaitov MR, Trinchieri G, Waisman A, Grivennikov SI.

  Immunity.
  Immunity. 2019 Jan 15;50(1):166-180.e7. doi: 10.1016/j.immuni.2018.11.015.

  
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• Microglial cell loss after ischemic stroke favors brain neutrophil accumulation.
  Otxoa-de-Amezaga A, Miró-Mur F, Pedragosa J, Gallizioli M, Justicia C, Gaja-Capdevila N, Ruíz-Jaen F, Salas-Perdomo A, Bosch A, Calvo M, Márquez-Kisinousky L, Denes A, Gunzer M, Planas AM.

  Acta Neuropathol.
  Acta Neuropathol. 2018 Dec 22. doi: 10.1007/s00401-018-1954-4. [Epub ahead of print]

  
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• Myeloid-derived suppressor cells control B cell accumulation in the central nervous system during autoimmunity
  Knier B, Hiltensperger M, Sie C, Aly L, Lepennetier G, Engleitner T, Garg G, Muschaweckh A, Mitsdörffer M, Koedel U, Höchst B, Knolle P, Gunzer M, Hemmer B, Rad R, Merkler D, Korn T

  Nat Immunol.
  Nat Immunol. 2018 Dec;19(12):1341-1351. doi: 10.1038/s41590-018-0237-5. Epub 2018 Oct 29.

  
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• Surveillance of Myelodysplastic Syndrome via Migration Analyses of Blood Neutrophils: A Potential Prognostic Tool.
  Schuster M, Moeller M, Bornemann L, Bessen C, Sobczak C, Schmitz S, Witjes L, Kruithoff K, Kohn C, Just O, Kündgen A, Pundt N, Pelzer B, Ampe C, Van Troys M, Nusch A, Haas R, Germing U, Martens L, Jöckel KH, Gunzer M

  J Immunol.
  J Immunol. 2018 Nov 16. pii: ji1801071. doi: 10.4049/jimmunol.1801071. [Epub ahead of print]

  
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• Neutrophils instruct homeostatic and pathological states in naive tissues.
  Casanova-Acebes M, Nicolás-Ávila JA, Li JL, García-Silva S, Balachander A, Rubio-Ponce A, Weiss LA, Adrover JM, Burrows K, A-González N, Ballesteros I, Devi S, Quintana JA, Crainiciuc G, Leiva M, Gunzer M, Weber C, Nagasawa T, Soehnlein O, Merad M, Mortha A, Ng LG, Peinado H, Hidalgo A.

  J Exp Med.
  J Exp Med. 2018 Oct 3. pii: jem.20181468. doi: 10.1084/jem.20181468. [Epub ahead of print]

  
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• Role of polymorphonuclear neutrophils in the reperfused ischemic brain: insights from cell-type-specific immunodepletion and fluorescence microscopy studies.
  Hermann DM, Kleinschnitz C, Gunzer M

  Ther Adv Neurol Disord.
  Ther Adv Neurol Disord. 2018 Sep 14;11:1756286418798607. doi: 10.1177/1756286418798607. eCollection 2018.

  
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• Modeling Hemolytic-Uremic Syndrome: In-Depth Characterization of Distinct Murine Models Reflecting Different Features of Human Disease.
  Dennhardt S, Pirschel W, Wissuwa B, Daniel C, Gunzer F, Lindig S, Medyukhina A, Kiehntopf M, Rudolph WW, Zipfel PF, Gunzer M, Figge MT, Amann K, Coldewey SM.

  Front Immunol.
  Front Immunol. 2018 Jun 25;9:1459. doi: 10.3389/fimmu.2018.01459. eCollection 2018.

  
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• Nanoparticle decoration impacts airborne fungal pathobiology.
  Westmeier D, Solouk-Saran D, Vallet C, Siemer S, Docter D, Götz H, Männ L, Hasenberg A, Hahlbrock A, Erler K, Reinhardt C, Schilling O, Becker S, Gunzer M, Hasenberg M, Knauer SK, Stauber RH.

  Proc Natl Acad Sci U S A
  Proc Natl Acad Sci U S A. 2018 Jun 20. pii: 201804542. doi: 10.1073/pnas.1804542115.

  
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• Hepatitis B virus is degraded by autophagosome-lysosome fusion mediated by Rab7 and related components
  Lin Y, Wu C, Wang X, Kemper T, Squire A, Gunzer M, Zhang J, Chen X, Lu M.

  Protein Cell.
  Protein Cell. 2018 Jun 6. doi: 10.1007/s13238-018-0555-2.

  
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• Implications of polymorphonuclear neutrophils for ischemic stroke and intracerebral hemorrhage: Predictive value, pathophysiological consequences and utility as therapeutic target.
  Hermann DM, Kleinschnitz C, Gunzer M.

  J Neuroimmunol.
  J Neuroimmunol. 2018 Apr 24. pii: S0165-5728(18)30168-1. doi: 10.1016/j.jneuroim.2018.04.015.

  
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• Mutual influence of immune system and bones.
  Kamradt T, Amling M, Dankbar B, Dudeck A, Gunzer M, Ignatius A, Krönke G, Kubatzky K, Pap T, Prinz I, Schett G, Schinke T, Tuckermann J, Waisman A.

  Z Rheumatol.
  Z Rheumatol. 2018 Apr 19. doi: 10.1007/s00393-018-0454-1.

  
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• How Safe is the Administration of Long-Acting Granulocyte Colony-Stimulating Factor in Cancer Patients?
  Geissler K, Gunzer M, Ostermann H.

  Oncol Res Treat.
  Oncol Res Treat. 2018 Mar 23;41(5). doi: 10.1159/000486681

  
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• Beware the intruder: Real time observation of infiltrated neutrophils and neutrophil—Microglia interaction during stroke in vivo
  Neumann J, Henneberg S, von Kenne S, Nolte N, Müller AJ, Schraven B, Görtler MW, Reymann KG, Gunzer M, Riek-Burchardt M.

  PLoS One
  PLoS One. 2018 Mar 15;13(3):e0193970. doi: 10.1371/journal.pone.0193970. eCollection 2018.

  
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• Respiratory Influenza A Virus Infection Triggers Local and Systemic Natural Killer Cell Activation via Toll-Like Receptor 7
  Stegemann-Koniszewski S, Behrens S, Boehme JD, Hochnadel I, Riese P, Guzmán CA, Kröger A, Schreiber J, Gunzer M, Bruder D.

  Front Immunol.
  Front Immunol. 2018 Feb 13;9:245. doi: 10.3389/fimmu.2018.00245. eCollection 2018.

  
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• Imaging of cytotoxic antiviral immunity while considering the 3R principle of animal research
  Otto L, Zelinskyy G, Schuster M, Dittmer U, Gunzer M.

  J Mol Med (Berl).
  J Mol Med (Berl). 2018 Feb 19. doi: 10.1007/s00109-018-1628-7.

  
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• ICAM1+ neutrophils promote chronic inflammation via ASPRV1 in B cell–dependent autoimmune encephalomyelitis
  Hawkins RFW, Patenaude A, Dumas A, Jain R, Tesfagiorgis Y, Kerfoot S, Matsui T, Gunzer M, Poubelle PE, Larochelle C, Pelletier M, Vallières L.

  JCI Insight.
  2017 Dec 7;2(23). pii: 96882. doi: 10.1172/jci.insight.96882. [Epub ahead of print]

  
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• Escaping the traps of your own hunters.
  Gunzer M.

  Science.
  2017 Dec 1;358(6367):1126-1127. doi: 10.1126/science.aar2428.

  
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• Visualizing the function and fate of neutrophils in sterile injury and repair.
  Wang J, Hossain M, Thanabalasuriar A, Gunzer M, Meininger C, Kubes P.

  Science.
  2017 Oct 6;358(6359):111-116. doi: 10.1126/science.aam9690.

  
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• Quantitative Analysis of Proteome Modulations in Alveolar Epithelial Type II Cells in Response to Pulmonary Aspergillus fumigatus Infection.
  Seddigh P, Bracht T, Molinier-Frenkel V, Castellano F, Kniemeyer O, Schuster M, Weski J, Hasenberg A, Kraus A, Poschet G, Hager T, Theegarte D, Opitz C, Brakhage AA, Sitek B, Hasenberg M, Gunzer M.

  Mol Cell Proteomics.
  2017 Sep 26. pii: mcp.000072.2017. doi: 10.1074/mcp.RA117.000072. [Epub ahead of print]

  
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• 3D cross-sectional imaging of the inflamed gut with Light Sheet Fluorescence Microscopy for translational research in IBD.
  Zundler S, Klingberg A, Schillinger D, Fischer S, Neufert C, Atreya I, Gunzer M, Neurath MF*.

  Gastroenterology.
  2017 Sep 1. pii: S0016-5085(17)35951-6. doi: 10.1053/j.gastro.2017.07.022. [Epub ahead of print]

  
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• Towards Translational ImmunoPET/MR Imaging of Invasive Pulmonary Aspergillosis: The Humanised Monoclonal Antibody JF5 Detects Aspergillus Lung Infections In Vivo.
  Davies G, Rolle AM, Maurer A, Spycher P, Schillinger C, Solouk-Saran D, Hasenberg M, Weski J, Fonslet J, Dubois A, Boschetti F, Denat F, Gunzer M, Eichner M, Ryder LS, Jensen M, Schibli R, Pichler BJ, Wiehr S, Thornton CR.

  Theranostics.
  2017 Aug 11;7(14):3398-3414. doi: 10.7150/thno.20919. eCollection 2017.

  
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• Rescue of T-cell function during persistent pulmonary adenoviral infection by TLR9 activation.
  Holland T, Wohlleber D, Marx S, Kreutzberg T, Vento-Asturias S, Schmitt-Mbamunyo C, Welz M, Janas M, Komander K, Eickhoff S, Brewitz A, Hasenberg M, Männ L, Gunzer M, Wilhelm C, Kastenmüller W, Knolle P, Abdullah Z, Kurts C, Garbi N*.

  J Allergy Clin Immunol.
  2017 Aug 18. pii: S0091-6749(17)31282-4. doi: 10.1016/j.jaci.2017.06.048. [Epub ahead of print]

  
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• Irf4-dependent CD103+CD11b+ dendritic cells and the intestinal microbiome regulate monocyte and macrophage activation and intestinal peristalsis in postoperative ileus.
  Pohl JM, Gutweiler S, Thiebes S, Volke JK, Klein-Hitpass L, Zwanziger D, Gunzer M, Jung S, Agace WW, Engel DR*, Kurts C.

  Gut.
  2017 Jun 14. pii: gutjnl-2017-313856. doi: 10.1136/gutjnl-2017-313856. [Epub ahead of print]

  
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• Quantitative Visualization of Leukocyte Infiltrate in a Murine Model of Fulminant Myocarditis by Light Sheet Microscopy.
  Männ L, Klingberg A, Gunzer M, Hasenberg M.

  J Vis Exp.
  2017 May 31;(123). doi: 10.3791/55450.

  
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• 3D visualization and quantification of microvessels in the whole ischemic mouse brain using solvent-based clearing and light sheet microscopy.
  Lugo-Hernandez E, Squire A, Hagemann N, Brenzel A, Sardari M, Schlechter J, Sanchez-Mendoza EH, Gunzer M, Faissner A, Hermann DM.

  J Cereb Blood Flow Metab.
  2017 Jan 1:271678X17698970. doi: 10.1177/0271678X17698970. [Epub ahead of print]

  
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• Fully Automated Evaluation of Total Glomerular Number and Capillary Tuft Size in Nephritic Kidneys Using Lightsheet Microscopy.
  Klingberg A, Hasenberg A, Ludwig-Portugall I, Medyukhina A, Männ L, Brenzel A, Engel DR, Figge MT, Kurts C, Gunzer M*.

  J Am Soc Nephrol.
  2017 Feb;28(2):452-459. doi: 10.1681/ASN.2016020232.

  
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• CD11c.DTR mice develop a fatal fulminant myocarditis after local or systemic treatment with diphtheria toxin.
  Männ L, Kochupurakkal N, Martin C, Verjans E, Klingberg A, Sody S, Kraus A, Dalimot J, Bergmüller E, Jung S, Voortman S, Winterhager E, Brandau S, Garbi N, Kurrer M, Eriksson U, Gunzer M, Hasenberg M*.

  Eur J Immunol.
  2016 Aug;46(8):2028-42. doi: 10.1002/eji.201546245.

  
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• Survival of residual neutrophils and accelerated myelopoiesis limit the efficacy of antibody-mediated depletion of Ly-6G+ cells in tumor-bearing mice.
  Moses K, Klein JC, Männ L, Klingberg A, Gunzer M, Brandau S*.

  J Leukoc Biol.
  2016 Jun;99(6):811-23. doi: 10.1189/jlb.1HI0715-289R.

  
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• Alveolar Type II Epithelial Cells Contribute to the Anti-Influenza A Virus Response in the Lung by Integrating Pathogen- and Microenvironment-Derived Signals.
  Stegemann-Koniszewski S*, Jeron A, Gereke M, Geffers R, Kröger A, Gunzer M, Bruder D.v

  MBio.
  2016 May 3;7(3). pii: e00276-16. doi: 10.1128/mBio.00276-16.

  
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• Neutrophil Migration into the Infected Uroepithelium Is Regulated by the Crosstalk between Resident and Helper Macrophages.
  Zec K, Volke J, Vijitha N, Thiebes S, Gunzer M, Kurts C, Engel DR*.

  Pathogens.
  2016 Feb 4;5(1). pii: E15. doi: 10.3390/pathogens5010015.

  
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• ImmunoPET/MR imaging allows specific detection of Aspergillus fumigatus lung infection in vivo.
  Rolle AM, Hasenberg M, Thornton CR, Solouk-Saran D, Männ L, Weski J, Maurer A, Fischer E, Spycher PR, Schibli R, Boschetti F, Stegemann-Koniszewski S, Bruder D, Severin GW, Autenrieth SE, Krappmann S, Davies G, Pichler BJ, Gunzer M*, Wiehr S*.

  Proc Natl Acad Sci U S A.
  2016 Feb 23;113(8):E1026-33. doi: 10.1073/pnas.1518836113.

  
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• Metastatic status of sentinel lymph nodes in melanoma determined noninvasively with multispectral optoacoustic imaging.
  Stoffels I, Morscher S, Helfrich I, Hillen U, Leyh J, Burton NC, Sardella TC, Claussen J, Poeppel TD, Bachmann HS, Roesch A, Griewank K, Schadendorf D, Gunzer M, Klode J*.

  Sci Transl Med.
  2015 Dec 9;7(317):317ra199. doi: 10.1126/scitranslmed.aad1278.

  
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• Role of Neutrophils in Exacerbation of Brain Injury After Focal Cerebral Ischemia in Hyperlipidemic Mice.
  Herz J, Sabellek P, Lane TE, Gunzer M, Hermann DM, Doeppner TR.

  Stroke.
  2015 Oct;46(10):2916-25. doi: 10.1161/STROKEAHA.115.010620.

  
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• Catchup: a mouse model for imaging-based tracking and modulation of neutrophil granulocytes.
  Hasenberg A, Hasenberg M, Männ L, Neumann F, Borkenstein L, Stecher M, Kraus A, Engel DR, Klingberg A, Seddigh P, Abdullah Z, Klebow S, Engelmann S, Reinhold A, Brandau S, Seeling M, Waisman A, Schraven B, Göthert JR, Nimmerjahn F, Gunzer M*.

  Nat Methods.
  2015 May;12(5):445-52. doi: 10.1038/nmeth.3322.

  
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• Very-late-antigen-4 (VLA-4)-mediated brain invasion by neutrophils leads to interactions with microglia, increased ischemic injury and impaired behavior in experimental stroke.
  Neumann J, Riek-Burchardt M, Herz J, Doeppner TR, König R, Hütten H, Etemire E, Männ L, Klingberg A, Fischer T, Görtler MW, Heinze HJ, Reichardt P, Schraven B, Hermann DM, Reymann KG, Gunzer M.

  Acta Neuropathol.
  2015 Feb;129(2):259-77. doi: 10.1007/s00401-014-1355-2.

  
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• Human dendritic cell subsets display distinct interactions with the pathogenic mould Aspergillus fumigatus.
  Lother J, Breitschopf T, Krappmann S, Morton CO, Bouzani M, Kurzai O, Gunzer M, Hasenberg M, Einsele H, Loeffler J*.

  Int J Med Microbiol.
  2014 Nov;304(8):1160-8. doi: 10.1016/j.ijmm.2014.08.009.

  
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• Traps and hyper inflammation - new ways that neutrophils promote or hinder survival.
  Gunzer M.

  Br J Haematol.
  2014 Jan;164(2):189-99. doi: 10.1111/bjh.12608. Review.

  
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• Automated characterization and parameter-free classification of cell tracks based on local migration behavior.
  Mokhtari Z, Mech F, Zitzmann C, Hasenberg M, Gunzer M, Figge MT.

  PLoS One.
  2013 Dec 6;8(12):e80808. doi: 10.1371/journal.pone.0080808. Erratum in: PLoS One. 2014;9(12):e115158.

  
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• Multimolecular analysis of stable immunological synapses reveals sustained recruitment and sequential assembly of signaling clusters.
  Philipsen L, Engels T, Schilling K, Gurbiel S, Fischer KD, Tedford K, Schraven B, Gunzer M, Reichardt P.

  Mol Cell Proteomics.
  2013 Sep;12(9):2551-67. doi: 10.1074/mcp.M112.025205.

  
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• Transiently reduced PI3K/Akt activity drives the development of regulatory function in antigen-stimulated Naïve T-cells.
  Etemire E, Krull M, Hasenberg M, Reichardt P*, Gunzer M*.

  PLoS One.
  2013 Jul 11;8(7):e68378. doi: 10.1371/journal.pone.0068378.

  
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• Mast cell and macrophage chemokines CXCL1/CXCL2 control the early stage of neutrophil recruitment during tissue inflammation.
  De Filippo K, Dudeck A, Hasenberg M, Nye E, van Rooijen N, Hartmann K, Gunzer M, Roers A, Hogg N.

  Blood.
  2013 Jun 13;121(24):4930-7. doi: 10.1182/blood-2013-02-486217.

  
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• A role for LFA-1 in delaying T-lymphocyte egress from lymph nodes.
  Reichardt P, Patzak I, Jones K, Etemire E, Gunzer M, Hogg N*.

  EMBO J.
  2013 Mar 20;32(6):829-43. doi: 10.1038/emboj.2013.33.

  
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• T cell activation results in conformational changes in the Src family kinase Lck to induce its activation.
  Stirnweiss A, Hartig R, Gieseler S, Lindquist JA, Reichardt P, Philipsen L, Simeoni L, Poltorak M, Merten C, Zuschratter W, Prokazov Y, Paster W, Stockinger H, Harder T, Gunzer M, Schraven B.

  Sci Signal.
  2013 Feb 19;6(263):ra13. doi: 10.1126/scisignal.2003607.

  
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• Cellular immune reactions in the lung.
  Hasenberg M, Stegemann-Koniszewski S, Gunzer M.

  Immunol Rev.
  2013 Jan;251(1):189-214. doi: 10.1111/imr.12020. Review.

  
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• White-opaque switching of Candida albicans allows immune evasion in an environment-dependent fashion.
  Sasse C, Hasenberg M, Weyler M, Gunzer M, Morschhäuser J.

  Eukaryot Cell.
  2013 Jan;12(1):50-8. doi: 10.1128/EC.00266-12.

  
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• TLR7 contributes to the rapid progression but not to the overall fatal outcome of secondary pneumococcal disease following influenza A virus infection.
  Stegemann-Koniszewski S, Gereke M, Orrskog S, Lienenklaus S, Pasche B, Bader SR, Gruber AD, Akira S, Weiss S, Henriques-Normark B, Bruder D, Gunzer M.

  J Innate Immun.
  2013;5(1):84-96. doi: 10.1159/000345112. Epub 2012 Nov 15.

  
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• Pilus adhesin RrgA interacts with complement receptor 3, thereby affecting macrophage function and systemic pneumococcal disease.
  Orrskog S, Rounioja S, Spadafina T, Gallotta M, Norman M, Hentrich K, Fälker S, Ygberg-Eriksson S, Hasenberg M, Johansson B, Uotila LM, Gahmberg CG, Barocchi M, Gunzer M, Normark S, Henriques-Normark B.

  MBio.
  2012 Dec 26;4(1):e00535-12. doi: 10.1128/mBio.00535-12.

  
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• Connexin-43 in the osteogenic BM niche regulates its cellular composition and the bidirectional traffic of hematopoietic stem cells and progenitors.
  Gonzalez-Nieto D, Li L, Kohler A, Ghiaur G, Ishikawa E, Sengupta A, Madhu M, Arnett JL, Santho RA, Dunn SK, Fishman GI, Gutstein DE, Civitelli R, Barrio LC, Gunzer M, Cancelas JA.

  Blood.
  2012 May 31;119(22):5144-54. doi: 10.1182/blood-2011-07-368506.

  
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• Cdc42 activity regulates hematopoietic stem cell aging and rejuvenation.
  Florian MC, Dörr K, Niebel A, Daria D, Schrezenmeier H, Rojewski M, Filippi MD, Hasenberg A, Gunzer M, Scharffetter-Kochanek K, Zheng Y, Geiger H*.

  Cell Stem Cell.
  2012 May 4;10(5):520-30. doi: 10.1016/j.stem.2012.04.007.

  
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• Vaccine adjuvants: Tailor-made mast-cell granules.
  Gunzer M.

  Nat Mater.
  2012 Feb 21;11(3):181-2. doi: 10.1038/nmat3257.

  
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• Surface display of Gaussia princeps luciferase allows sensitive fungal pathogen detection during cutaneous aspergillosis.
  Donat S, Hasenberg M, Schäfer T, Ohlsen K, Gunzer M, Einsele H, Löffler J, Beilhack A, Krappmann S*.

  Virulence.
  2012 Jan-Feb;3(1):51-61. Epub 2012 Jan 1.

  
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• Human Regulatory T Cells Rapidly Suppress T Cell Receptor–Induced Ca2+, NF-?B, and NFAT Signaling in Conventional T Cells
  Schmidt A, Oberle N, Weiss EM, Vobis D, Frischbutter S, Baumgrass R, Falk CS, Haag M, Brügger B, Lin H, Mayr GW, Reichardt P, Gunzer M, Suri-Payer E, Krammer PH*.

  Sci Signal.
  2011 Dec 20;4(204):ra90

  
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• On the way toward systems biology of Aspergillus fumigatus infection.
  Albrecht D, Kniemeyer O, Mech F, Gunzer M, Brakhage A, Guthke R*.

  Int J Med Microbiol.
  2011 Jun;301(5):453-9. Epub 2011 May 8.

  
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• Shaping the fungal adaptome - Stress responses of Aspergillus fumigatus.
  Hartmann T, Sasse C, Schedler A, Hasenberg M, Gunzer M, Krappmann S*.

  Int J Med Microbiol.
  2011 Jun;301(5):408-16. Epub 2011 May 11.

  
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• Phagocyte responses towards Aspergillus fumigatus.
  Hasenberg M*, Behnsen J, Krappmann S, Brakhage A, Gunzer M*.

  Int J Med Microbiol.
  2011 Jun;301(5):436-44. Epub 2011 May 14.

  
  URL
• Mast cells are key promoters of contact allergy that mediate the adjuvant effects of haptens.
  Dudeck A, Dudeck J, Scholten J, Petzold A, Surianarayanan S, Köhler A, Peschke K, Voehringer D, Waskow C, Krieg T, Müller W, Waisman A, Hartmann K, Gunzer M*, Roers A*.

  Immunity.
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• Direct observation of phagocytosis and NET-formation by neutrophils in infected lungs using 2-photon microscopy.
  Hasenberg M, Köhler A, Bonifatius S, Jeron A, Gunzer M.

  J Vis Exp.
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• Sphingosine 1-phosphate-induced motility and endocytosis of dendritic cells is regulated by SWAP-70 through RhoA.
  Ocaña-Morgner C, Reichardt P, Chopin M, Braungart S, Wahren C, Gunzer M, Jessberger R.

  J Immunol.
  2011 May 1;186(9):5345-55. Epub 2011 Mar 18.

  
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• Imaging Hematopoietic Stem Cells in the Marrow of Long Bones In Vivo.
  Köhler A, Geiger H, Gunzer M.

  Methods Mol Biol.
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• G-CSF-mediated thrombopoietin release triggers neutrophil motility and mobilization from bone marrow via induction of Cxcr2 ligands.
  Köhler A, De Filippo K, Hasenberg M, van den Brandt C, Nye E, Hosking MP, Lane TE, Männ L, Ransohoff RM, Hauser AE, Winter O, Schraven B, Geiger H, Hogg N, Gunzer M.

  Blood.
  2011 Apr 21;117(16):4349-57. Epub 2011 Jan 11.

  
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• Rapid immunomagnetic negative enrichment of neutrophil granulocytes from murine bone marrow for functional studies in vitro and in vivo.
  Hasenberg M, Köhler A, Bonifatius S, Borucki K, Riek-Burchardt M, Achilles J, Männ L, Baumgart K, Schraven B, Gunzer M*.

  PLoS One.
  2011 Feb 23;6 (2):e17314.

  
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• Pharmacological inhibition of EGFR signaling enhances G-CSF-induced hematopoietic stem cell mobilization.
  Ryan MA, Nattamai KJ, Xing E, Schleimer D, Daria D, Sengupta A, Köhler A, Liu W, Gunzer M, Jansen M, Ratner N, Le Cras TD, Waterstrat A, Van Zant G, Cancelas JA, Zheng Y, Geiger H*.

  Nat Med.
  2010 Oct;16(10):1141-6. Epub 2010 Sep 26.

  
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• Toll-like receptor 4 signaling by follicular dendritic cells is pivotal for germinal center onset and affinity maturation.
  Garin A, Meyer-Hermann M, Contie M, Figge MT, Buatois V, Gunzer M, Toellner KM, Elson G, Kosco-Vilbois MH*.

  Immunity.
  2010 Jul 23;33(1):84-95. doi:10.1016/j.immuni.2010.07.005.

  
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• Production of extracellular traps against Aspergillus fumigatus in vitro and in infected lung tissue is dependent on invading neutrophils and influenced by hydrophobin RodA.
  Bruns S, Kniemeyer O, Hasenberg M, Aimanianda V, Nietzsche S, Thywissen A, Jeron A, Latgé JP, Brakhage AA*, Gunzer M*.

  PLoS Pathog.
  2010 Apr 29;6(4):e1000873.

  
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• APC, T cells, and the immune synapse.
  Reichardt P, Dornbach B, Gunzer M.

  Curr Top Microbiol Immunol.
  2010;340:229-49. Review.

  
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• Imaging Immunity.
  Reichardt P, Hämmerling G, Gunzer M.

  Eur J Immunol.
  2009 Dec;39(12):3279-82.

  
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• Src homology 2-domain containing leukocyte-specific phosphoprotein of 76 kDa is mandatory for TCR-mediated inside-out signaling, but dispensable for CXCR4-mediated LFA-1 activation, adhesion, and migration of T cells.
  Horn J, Wang X, Reichardt P, Stradal TE, Warnecke N, Simeoni L, Gunzer M, Yablonski D, Schraven B, Kliche S.

  J Immunol.
  2009 Nov 1;183(9):5756-67. Epub 2009 Oct 7.

  
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• Immune synapse formation determines interaction forces between T cells and antigen-presenting cells measured by atomic force microscopy.
  Hosseini BH, Louban I, Djandji D, Wabnitz GH, Deeg J, Bulbuc N, Samstag Y, Gunzer M, Spatz JP, Hämmerling GJ.

  Proc Natl Acad Sci U S A.
  2009 Oct 20;106(42):17852-7. Epub 2009 Oct 12.

  
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• Identification of a putative Crf splice variant and generation of recombinant antibodies for the specific detection of Aspergillus fumigatus.
  Schütte M, Thullier P, Pelat T, Wezler X, Rosenstock P, Hinz D, Kirsch MI, Hasenberg M, Frank R, Schirrmann T, Gunzer M, Hust M, Dübel S*.

  PLoS One.
  2009 Aug 13;4(8):e6625.

  
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• Altered cellular dynamics and endosteal location of aged early hematopoietic progenitor cells revealed by time-lapse intravital imaging in long bones.
  Köhler A, Schmithorst V, Filippi MD, Ryan MA, Daria D, Gunzer M*, Geiger H*.

  Blood.
  2009 Jul 9;114(2):290-8. Epub 2009 Apr 8.

  
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• Retrospective: Birth of the cool - imaging and microbiology from Ibn al-Haytham to Jean Comandon.
  Frischknecht F, Gunzer M, Shorte SL.

  Biotechnol J.
  2009 Jun;4(6):787-90.

  
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• Human chorionic gonadotropin attracts regulatory T cells into the fetal-maternal interface during early human pregnancy.
  Schumacher A, Brachwitz N, Sohr S, Engeland K, Langwisch S, Dolaptchieva M, Alexander T, Taran A, Malfertheiner SF, Costa SD, Zimmermann G, Nitschke C, Volk HD, Alexander H, Gunzer M, Zenclussen AC.

  J Immunol.
  2009 May 1;182(9):5488-97.

  
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• Guanine nucleotide-binding proteins of the G12 family shape immune functions by controlling CD4+ T cell adhesiveness and motility.
  Herroeder S, Reichardt P, Sassmann A, Zimmermann B, Jaeneke D, Hoeckner J, Hollmann MW, Fischer KD, Vogt S, Grosse R, Hogg N, Gunzer M, Offermanns S, Wettschureck N*.

  Immunity.
  2009 May;30(5):708-20. Epub 2009 Apr 30.

  
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• Increased susceptibility for superinfection with Streptococcus pneumoniae during influenza virus infection is not caused by TLR7-mediated lymphopenia.
  Stegemann S, Dahlberg S, Kröger A, Gereke M, Bruder D, Henriques-Normark B, Gunzer M*.

  PLoS One.
  2009 Mar;4(3):e4840. Epub 2009 Mar 17.

  
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• 3D and 4D imaging of immune cells in vitro and in vivo.
  Nitschke C, Garin A, Kosco-Vilbois M, Gunzer M*.

  Histochem Cell Biol.
  2008 Dec;130(6):1053-62. Epub 2008 Oct 15.

  
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• Deriving a germinal center lymphocyte migration model from two-photon data.
  Figge MT, Garin A, Gunzer M, Kosco-Vilbois M, Toellner KM, Meyer-Hermann M.

  J Exp Med.
  2008 Dec 22;205(13):3019-29. Epub 2008 Dec 1.

  
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• Selective detection of NADPH oxidase in polymorphonuclear cells by means of NAD(P)H-based fluorescence lifetime imaging.
  Niesner R, Narang P, Spiecker H, Andresen V, Gericke KH, Gunzer M.

  J Biophys.
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• Microglia cells protect neurons by direct engulfment of invading neutrophil granulocytes: a new mechanism of CNS immune privilege.
  Neumann J, Sauerzweig S, Rönicke R, Gunzer F, Dinkel K, Ullrich O, Gunzer M*, Reymann KG*.

  J Neurosci.
  2008 Jun 4;28(23):5965-75.

  
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• Basal expression of the Aspergillus fumigatus transcriptional activator CpcA is sufficient to support pulmonary aspergillosis.
  Sasse C, Bignell EM, Hasenberg M, Haynes K, Gunzer M, Braus GH, Krappmann S*.

  Fungal Genet Biol.
  2008 May;45(5):693-704. Epub 2008 Jan 3.

  
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• Signaling signatures and functional properties of anti-human CD28 superagonistic antibodies.
  Waibler Z, Sender LY, Merten C, Hartig R, Kliche S, Gunzer M, Reichardt P, Kalinke U*, Schraven B*.

  PLoS One.
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• Intravital two-photon microscopy: focus on speed and time resolved imaging modalities.
  Niesner RA, Andresen V, Gunzer M.

  Immunol Rev.
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• The power of single and multibeam two-photon microscopy for high-resolution and high-speed deep tissue and intravital imaging.
  Niesner R*, Andresen V, Neumann J, Spiecker H, Gunzer M*.

  Biophys J.
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• Vitamin D receptor signaling contributes to susceptibility to infection with Leishmania major.
  Ehrchen J, Helming L, Varga G, Pasche B, Loser K, Gunzer M, Sunderkötter C, Sorg C, Roth J, Lengeling A*.

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• Naive B cells generate regulatory T cells in the presence of a mature immunologic synapse.
  Reichardt P, Dornbach B, Rong S, Beissert S, Gueler F, Loser K, Gunzer M.

  Blood.
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• The molecular makeup and function of regulatory and effector synapses.
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  Immunol Rev.
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• Stem cells, aging, niche, adhesion and Cdc42: a model for changes in cell-cell interactions and hematopoietic stem cell aging.
  Geiger H, Koehler A, Gunzer M.

  Cell Cycle.
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• Imaging the immunological synapse.
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  Eur J Immunol.
  2007 Feb;37(2):299-300.

  
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• Environmental dimensionality controls the interaction of phagocytes with the pathogenic fungi Aspergillus fumigatus and Candida albicans.
  Behnsen J, Narang P, Hasenberg M, Gunzer F, Bilitewski U, Klippel N, Rohde M, Brock M, Brakhage AA, Gunzer M*.

  PLoS Pathog.
  2007 Feb;3(2):e13.

  
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• Analyzing the physicodynamics of immune cells in a three-dimensional collagen matrix.
  Reichardt P, Gunzer F, Gunzer M.

  Methods Mol Biol.
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• Migration, cell-cell interaction and adhesion in the immune system.
  Gunzer M.

  Ernst Schering Found Symp Proc.
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• Immune response modifiers--mode of action.
  Schiller M*, Metze D, Luger TA, Grabbe S, Gunzer M.

  Exp Dermatol.
  2006 May;15(5):331-41.

  
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• Microglia provide neuroprotection after ischemia.
  Neumann J, Gunzer M, Gutzeit HO, Ullrich O, Reymann KG, Dinkel K*.

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• The biophysics of T lymphocyte activation in vitro and in vivo.
  Reichardt P, Gunzer M.

  Results Probl Cell Differ.
  2006;43:199-218.

  
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• Systemic administration of a TLR7 ligand leads to transient immune incompetence due to peripheral-blood leukocyte depletion.
  Gunzer M, Riemann H, Basoglu Y, Hillmer A, Weishaupt C, Balkow S, Benninghoff B, Ernst B, Steinert M, Scholzen T, Sunderkötter C, Grabbe S.

  Blood.
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• Tuning immune responses: diversity and adaptation of the immunological synapse.
  Friedl P, den Boer AT, Gunzer M.

  Nat Rev Immunol.
  2005 Jul;5(7):532-45.

  
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• The Mycoplasma-derived macrophage-activating 2-kilodalton lipopeptide triggers global immune activation on nasal mucosa-associated lymphoid tissues.
  Rharbaoui F, Westendorf A, Link C, Felk S, Buer J, Gunzer M, Guzmán CA*.

  Infect Immun.
  2004 Dec;72(12):6978-86.

  
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• A spectrum of biophysical interaction modes between T cells and different antigen-presenting cells during priming in 3-D collagen and in vivo.
  Gunzer M, Weishaupt C, Hillmer A, Basoglu Y, Friedl P, Dittmar KE, Kolanus W, Varga G, Grabbe S.

  Blood.
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• Agonists of proteinase-activated receptor-2 modulate human neutrophil cytokine secretion, expression of cell adhesion molecules, and migration within 3-D collagen lattices.
  Shpacovitch VM, Varga G, Strey A, Gunzer M, Mooren F, Buddenkotte J, Vergnolle N, Sommerhoff CP, Grabbe S, Gerke V, Homey B, Hollenberg M, Luger TA, Steinhoff M.

  J Leukoc Biol.
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• Molecular and functional analysis of Shiga toxin-induced response patterns in human vascular endothelial cells.
  Matussek A, Lauber J, Bergau A, Hansen W, Rohde M, Dittmar KE, Gunzer M, Mengel M, Gatzlaff P, Hartmann M, Buer J, Gunzer F.

  Blood.
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• Loss of S100A9 (MRP14) results in reduced interleukin-8-induced CD11b surface expression, a polarized microfilament system, and diminished responsiveness to chemoattractants in vitro.
  Manitz MP, Horst B, Seeliger S, Strey A, Skryabin BV, Gunzer M, Frings W, Schönlau F, Roth J, Sorg C, Nacken W*.

  Mol Cell Biol.
  2003 Feb;23(3):1034-43.

  
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• Localization of mu-opioid receptor 1A on sensory nerve fibers in human skin.
  Ständer S*, Gunzer M, Metze D, Luger T, Steinhoff M.

  Regul Pept.
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• DC–T-cell synapses
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  Trends Immunol.
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• Two-step negative enrichment of CD4+ and CD8+ T cells from murine spleen via nylon wool adherence and an optimized antibody cocktail.
  Gunzer M*, Weishaupt C, Planelles L, Grabbe S.

  J Immunol Methods.
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• Dendritic cells and tumor immunity.
  Gunzer M, Jänich S, Varga G, Grabbe S.

  Semin Immunol.
  2001 Oct;13(5):291-302.

  
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• The fate of T cells after conditional ablation of TCR.
  Gunzer M, Grabbe S*.

  Trends Immunol.
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• A holistic view of memory generation: where do T cells reside?
  Gunzer M, Grabbe S*.

  Trends Immunol.
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• Interaction of T cells with APCs: the serial encounter model.
  Friedl P, Gunzer M.

  Trends Immunol.
  2001 Apr;22(4):187-91.

  
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• Dendritic cells in cancer immunotherapy.
  Gunzer M, Grabbe S.

  Crit Rev Immunol.
  2001;21(1-3):133-45.

  
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• Antigen Presentation in Extracellular Matrix: Interactions of T Cells with Dendritic Cells Are Dynamic, Short Lived, and Sequential.
  Gunzer M, Schäfer A, Borgmann S, Grabbe S, Zänker KS, Bröcker EB, Kämpgen E, Friedl P*.

  Immunity.
  2000 Sep;13(3):323-32.

  
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• Evidence for functional relevance of CTLA-4 in ultraviolet-radiation-induced tolerance.
  Schwarz A, Beissert S, Grosse-Heitmeyer K, Gunzer M, Bluestone JA, Grabbe S, Schwarz T.

  J Immunol.
  2000 Aug 15;165(4):1824-31.

  
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• Migration of dendritic cells within 3-D collagen lattices is dependent on tissue origin, state of maturation, and matrix structure and is maintained by proinflammatory cytokines.
  Gunzer M, Friedl P, Niggemann B, Bröcker EB, Kämpgen E, Zänker KS.

  J Leukoc Biol.
  2000 May;67(5):622-9.

  
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• T Lymphocytes and Neutrophil Granulocytes Differ in Regulatory Signaling and Migratory Dynamics with Regard to Spontaneous Locomotion and Chemotaxis.
  Entschladen F, Gunzer M, Scheuffele CM, Niggemann B, Zänker KS.

  Cell Immunol.
  2000 Feb 1;199(2):104-14.

  
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• Migration of dendritic cells in 3D-collagen lattices. Visualisation of dynamic interactions with the substratum and the distribution of surface structures via a novel confocal reflection imaging technique.
  Gunzer M, Kämpgen E, Bröcker EB, Zänker KS, Friedl P.

  Adv Exp Med Biol.
  1997;417:97-103.

  
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