Alle Publikationen
* corresponding author
-
Mutual influence of immune system and bones.Z Rheumatol.
Z Rheumatol. 2018 Apr 19. doi: 10.1007/s00393-018-0454-1. -
How Safe is the Administration of Long-Acting Granulocyte Colony-Stimulating Factor in Cancer Patients?Oncol Res Treat.
Oncol Res Treat. 2018 Mar 23;41(5). doi: 10.1159/000486681 -
Beware the intruder: Real time observation of infiltrated neutrophils and neutrophil—Microglia interaction during stroke in vivoPLoS One
PLoS One. 2018 Mar 15;13(3):e0193970. doi: 10.1371/journal.pone.0193970. eCollection 2018. -
Respiratory Influenza A Virus Infection Triggers Local and Systemic Natural Killer Cell Activation via Toll-Like Receptor 7Front Immunol.
Front Immunol. 2018 Feb 13;9:245. doi: 10.3389/fimmu.2018.00245. eCollection 2018. -
Imaging of cytotoxic antiviral immunity while considering the 3R principle of animal researchJ Mol Med (Berl).
J Mol Med (Berl). 2018 Feb 19. doi: 10.1007/s00109-018-1628-7. -
ICAM1+ neutrophils promote chronic inflammation via ASPRV1 in B cell–dependent autoimmune encephalomyelitisJCI Insight.
2017 Dec 7;2(23). pii: 96882. doi: 10.1172/jci.insight.96882. [Epub ahead of print] -
Escaping the traps of your own hunters.Science.
2017 Dec 1;358(6367):1126-1127. doi: 10.1126/science.aar2428. -
Visualizing the function and fate of neutrophils in sterile injury and repair.Science.
2017 Oct 6;358(6359):111-116. doi: 10.1126/science.aam9690. -
Quantitative Analysis of Proteome Modulations in Alveolar Epithelial Type II Cells in Response to Pulmonary Aspergillus fumigatus Infection.Mol Cell Proteomics.
2017 Sep 26. pii: mcp.000072.2017. doi: 10.1074/mcp.RA117.000072. [Epub ahead of print] -
3D cross-sectional imaging of the inflamed gut with Light Sheet Fluorescence Microscopy for translational research in IBD.Gastroenterology.
2017 Sep 1. pii: S0016-5085(17)35951-6. doi: 10.1053/j.gastro.2017.07.022. [Epub ahead of print] -
Towards Translational ImmunoPET/MR Imaging of Invasive Pulmonary Aspergillosis: The Humanised Monoclonal Antibody JF5 Detects Aspergillus Lung Infections In Vivo.Theranostics.
2017 Aug 11;7(14):3398-3414. doi: 10.7150/thno.20919. eCollection 2017. -
Rescue of T-cell function during persistent pulmonary adenoviral infection by TLR9 activation.J Allergy Clin Immunol.
2017 Aug 18. pii: S0091-6749(17)31282-4. doi: 10.1016/j.jaci.2017.06.048. [Epub ahead of print] -
Irf4-dependent CD103+CD11b+ dendritic cells and the intestinal microbiome regulate monocyte and macrophage activation and intestinal peristalsis in postoperative ileus.Gut.
2017 Jun 14. pii: gutjnl-2017-313856. doi: 10.1136/gutjnl-2017-313856. [Epub ahead of print] -
Quantitative Visualization of Leukocyte Infiltrate in a Murine Model of Fulminant Myocarditis by Light Sheet Microscopy.J Vis Exp.
2017 May 31;(123). doi: 10.3791/55450. -
3D visualization and quantification of microvessels in the whole ischemic mouse brain using solvent-based clearing and light sheet microscopy.J Cereb Blood Flow Metab.
2017 Jan 1:271678X17698970. doi: 10.1177/0271678X17698970. [Epub ahead of print] -
Fully Automated Evaluation of Total Glomerular Number and Capillary Tuft Size in Nephritic Kidneys Using Lightsheet Microscopy.J Am Soc Nephrol.
2017 Feb;28(2):452-459. doi: 10.1681/ASN.2016020232. -
CD11c.DTR mice develop a fatal fulminant myocarditis after local or systemic treatment with diphtheria toxin.Eur J Immunol.
2016 Aug;46(8):2028-42. doi: 10.1002/eji.201546245. -
Survival of residual neutrophils and accelerated myelopoiesis limit the efficacy of antibody-mediated depletion of Ly-6G+ cells in tumor-bearing mice.J Leukoc Biol.
2016 Jun;99(6):811-23. doi: 10.1189/jlb.1HI0715-289R. -
Alveolar Type II Epithelial Cells Contribute to the Anti-Influenza A Virus Response in the Lung by Integrating Pathogen- and Microenvironment-Derived Signals.MBio.
2016 May 3;7(3). pii: e00276-16. doi: 10.1128/mBio.00276-16. -
Neutrophil Migration into the Infected Uroepithelium Is Regulated by the Crosstalk between Resident and Helper Macrophages.Pathogens.
2016 Feb 4;5(1). pii: E15. doi: 10.3390/pathogens5010015. -
ImmunoPET/MR imaging allows specific detection of Aspergillus fumigatus lung infection in vivo.Proc Natl Acad Sci U S A.
2016 Feb 23;113(8):E1026-33. doi: 10.1073/pnas.1518836113. -
Metastatic status of sentinel lymph nodes in melanoma determined noninvasively with multispectral optoacoustic imaging.Sci Transl Med.
2015 Dec 9;7(317):317ra199. doi: 10.1126/scitranslmed.aad1278. -
Role of Neutrophils in Exacerbation of Brain Injury After Focal Cerebral Ischemia in Hyperlipidemic Mice.Stroke.
2015 Oct;46(10):2916-25. doi: 10.1161/STROKEAHA.115.010620. -
Catchup: a mouse model for imaging-based tracking and modulation of neutrophil granulocytes.Nat Methods.
2015 May;12(5):445-52. doi: 10.1038/nmeth.3322. -
Very-late-antigen-4 (VLA-4)-mediated brain invasion by neutrophils leads to interactions with microglia, increased ischemic injury and impaired behavior in experimental stroke.Acta Neuropathol.
2015 Feb;129(2):259-77. doi: 10.1007/s00401-014-1355-2. -
Human dendritic cell subsets display distinct interactions with the pathogenic mould Aspergillus fumigatus.Int J Med Microbiol.
2014 Nov;304(8):1160-8. doi: 10.1016/j.ijmm.2014.08.009. -
Traps and hyper inflammation - new ways that neutrophils promote or hinder survival.Br J Haematol.
2014 Jan;164(2):189-99. doi: 10.1111/bjh.12608. Review. -
Automated characterization and parameter-free classification of cell tracks based on local migration behavior.PLoS One.
2013 Dec 6;8(12):e80808. doi: 10.1371/journal.pone.0080808. Erratum in: PLoS One. 2014;9(12):e115158. -
Multimolecular analysis of stable immunological synapses reveals sustained recruitment and sequential assembly of signaling clusters.Mol Cell Proteomics.
2013 Sep;12(9):2551-67. doi: 10.1074/mcp.M112.025205. -
Transiently reduced PI3K/Akt activity drives the development of regulatory function in antigen-stimulated Naïve T-cells.PLoS One.
2013 Jul 11;8(7):e68378. doi: 10.1371/journal.pone.0068378. -
Mast cell and macrophage chemokines CXCL1/CXCL2 control the early stage of neutrophil recruitment during tissue inflammation.Blood.
2013 Jun 13;121(24):4930-7. doi: 10.1182/blood-2013-02-486217. -
A role for LFA-1 in delaying T-lymphocyte egress from lymph nodes.EMBO J.
2013 Mar 20;32(6):829-43. doi: 10.1038/emboj.2013.33. -
T cell activation results in conformational changes in the Src family kinase Lck to induce its activation.Sci Signal.
2013 Feb 19;6(263):ra13. doi: 10.1126/scisignal.2003607. -
Cellular immune reactions in the lung.Immunol Rev.
2013 Jan;251(1):189-214. doi: 10.1111/imr.12020. Review. -
White-opaque switching of Candida albicans allows immune evasion in an environment-dependent fashion.Eukaryot Cell.
2013 Jan;12(1):50-8. doi: 10.1128/EC.00266-12. -
TLR7 contributes to the rapid progression but not to the overall fatal outcome of secondary pneumococcal disease following influenza A virus infection.J Innate Immun.
2013;5(1):84-96. doi: 10.1159/000345112. Epub 2012 Nov 15. -
Pilus adhesin RrgA interacts with complement receptor 3, thereby affecting macrophage function and systemic pneumococcal disease.MBio.
2012 Dec 26;4(1):e00535-12. doi: 10.1128/mBio.00535-12. -
Connexin-43 in the osteogenic BM niche regulates its cellular composition and the bidirectional traffic of hematopoietic stem cells and progenitors.Blood.
2012 May 31;119(22):5144-54. doi: 10.1182/blood-2011-07-368506. -
Cdc42 activity regulates hematopoietic stem cell aging and rejuvenation.Cell Stem Cell.
2012 May 4;10(5):520-30. doi: 10.1016/j.stem.2012.04.007. -
Vaccine adjuvants: Tailor-made mast-cell granules.Nat Mater.
2012 Feb 21;11(3):181-2. doi: 10.1038/nmat3257. -
Surface display of Gaussia princeps luciferase allows sensitive fungal pathogen detection during cutaneous aspergillosis.Virulence.
2012 Jan-Feb;3(1):51-61. Epub 2012 Jan 1. -
Human Regulatory T Cells Rapidly Suppress T Cell Receptor–Induced Ca2+, NF-?B, and NFAT Signaling in Conventional T CellsSci Signal.
2011 Dec 20;4(204):ra90 -
On the way toward systems biology of Aspergillus fumigatus infection.Int J Med Microbiol.
2011 Jun;301(5):453-9. Epub 2011 May 8. -
Shaping the fungal adaptome - Stress responses of Aspergillus fumigatus.Int J Med Microbiol.
2011 Jun;301(5):408-16. Epub 2011 May 11. -
Phagocyte responses towards Aspergillus fumigatus.Int J Med Microbiol.
2011 Jun;301(5):436-44. Epub 2011 May 14. -
Mast cells are key promoters of contact allergy that mediate the adjuvant effects of haptens.Immunity.
2011 Jun 24;34(6):973-84. -
Direct observation of phagocytosis and NET-formation by neutrophils in infected lungs using 2-photon microscopy.J Vis Exp.
2011 Jun 2;(52). pii: 2659. doi: 10.3791/2659. -
Sphingosine 1-phosphate-induced motility and endocytosis of dendritic cells is regulated by SWAP-70 through RhoA.J Immunol.
2011 May 1;186(9):5345-55. Epub 2011 Mar 18. -
Imaging Hematopoietic Stem Cells in the Marrow of Long Bones In Vivo.Methods Mol Biol.
2011 May;750:215-224. -
G-CSF-mediated thrombopoietin release triggers neutrophil motility and mobilization from bone marrow via induction of Cxcr2 ligands.Blood.
2011 Apr 21;117(16):4349-57. Epub 2011 Jan 11. -
Rapid immunomagnetic negative enrichment of neutrophil granulocytes from murine bone marrow for functional studies in vitro and in vivo.PLoS One.
2011 Feb 23;6 (2):e17314. -
Pharmacological inhibition of EGFR signaling enhances G-CSF-induced hematopoietic stem cell mobilization.Nat Med.
2010 Oct;16(10):1141-6. Epub 2010 Sep 26. -
Toll-like receptor 4 signaling by follicular dendritic cells is pivotal for germinal center onset and affinity maturation.Immunity.
2010 Jul 23;33(1):84-95. doi:10.1016/j.immuni.2010.07.005. -
Production of extracellular traps against Aspergillus fumigatus in vitro and in infected lung tissue is dependent on invading neutrophils and influenced by hydrophobin RodA.PLoS Pathog.
2010 Apr 29;6(4):e1000873. -
APC, T cells, and the immune synapse.Curr Top Microbiol Immunol.
2010;340:229-49. Review. -
Imaging Immunity.Eur J Immunol.
2009 Dec;39(12):3279-82. -
Src homology 2-domain containing leukocyte-specific phosphoprotein of 76 kDa is mandatory for TCR-mediated inside-out signaling, but dispensable for CXCR4-mediated LFA-1 activation, adhesion, and migration of T cells.J Immunol.
2009 Nov 1;183(9):5756-67. Epub 2009 Oct 7. -
Immune synapse formation determines interaction forces between T cells and antigen-presenting cells measured by atomic force microscopy.Proc Natl Acad Sci U S A.
2009 Oct 20;106(42):17852-7. Epub 2009 Oct 12. -
Identification of a putative Crf splice variant and generation of recombinant antibodies for the specific detection of Aspergillus fumigatus.PLoS One.
2009 Aug 13;4(8):e6625. -
Altered cellular dynamics and endosteal location of aged early hematopoietic progenitor cells revealed by time-lapse intravital imaging in long bones.Blood.
2009 Jul 9;114(2):290-8. Epub 2009 Apr 8. -
Retrospective: Birth of the cool - imaging and microbiology from Ibn al-Haytham to Jean Comandon.Biotechnol J.
2009 Jun;4(6):787-90. -
Human chorionic gonadotropin attracts regulatory T cells into the fetal-maternal interface during early human pregnancy.J Immunol.
2009 May 1;182(9):5488-97. -
Guanine nucleotide-binding proteins of the G12 family shape immune functions by controlling CD4+ T cell adhesiveness and motility.Immunity.
2009 May;30(5):708-20. Epub 2009 Apr 30. -
Increased susceptibility for superinfection with Streptococcus pneumoniae during influenza virus infection is not caused by TLR7-mediated lymphopenia.PLoS One.
2009 Mar;4(3):e4840. Epub 2009 Mar 17. -
3D and 4D imaging of immune cells in vitro and in vivo.Histochem Cell Biol.
2008 Dec;130(6):1053-62. Epub 2008 Oct 15. -
Deriving a germinal center lymphocyte migration model from two-photon data.J Exp Med.
2008 Dec 22;205(13):3019-29. Epub 2008 Dec 1. -
Selective detection of NADPH oxidase in polymorphonuclear cells by means of NAD(P)H-based fluorescence lifetime imaging.J Biophys.
2008:602639. Epub 2008 Nov 16. -
Microglia cells protect neurons by direct engulfment of invading neutrophil granulocytes: a new mechanism of CNS immune privilege.J Neurosci.
2008 Jun 4;28(23):5965-75. -
Basal expression of the Aspergillus fumigatus transcriptional activator CpcA is sufficient to support pulmonary aspergillosis.Fungal Genet Biol.
2008 May;45(5):693-704. Epub 2008 Jan 3. -
Signaling signatures and functional properties of anti-human CD28 superagonistic antibodies.PLoS One.
2008 Mar 5;3(3):e1708. -
Intravital two-photon microscopy: focus on speed and time resolved imaging modalities.Immunol Rev.
2008 Feb;221:7-25. -
The power of single and multibeam two-photon microscopy for high-resolution and high-speed deep tissue and intravital imaging.Biophys J.
2007 Oct 1;93(7):2519-29. Epub 2007 Jun 8. -
Vitamin D receptor signaling contributes to susceptibility to infection with Leishmania major.FASEB J.
2007 Oct;21(12):3208-18. Epub 2007 Jun 5. -
Naive B cells generate regulatory T cells in the presence of a mature immunologic synapse.Blood.
2007 Sep 1;110(5):1519-29. Epub 2007 Mar 28. -
The molecular makeup and function of regulatory and effector synapses.Immunol Rev.
2007 Aug;218:165-77. -
Stem cells, aging, niche, adhesion and Cdc42: a model for changes in cell-cell interactions and hematopoietic stem cell aging.Cell Cycle.
2007 Apr 15;6(8):884-7. Epub 2007 Apr 7. -
Imaging the immunological synapse.Eur J Immunol.
2007 Feb;37(2):299-300. -
Environmental dimensionality controls the interaction of phagocytes with the pathogenic fungi Aspergillus fumigatus and Candida albicans.PLoS Pathog.
2007 Feb;3(2):e13. -
Analyzing the physicodynamics of immune cells in a three-dimensional collagen matrix.Methods Mol Biol.
2007;380:253-69. -
Migration, cell-cell interaction and adhesion in the immune system.Ernst Schering Found Symp Proc.
2007;(3):97-137. -
Immune response modifiers--mode of action.Exp Dermatol.
2006 May;15(5):331-41. -
Microglia provide neuroprotection after ischemia.FASEB J.
2006 Apr;20(6):714-6. Epub 2006 Feb 10. -
The biophysics of T lymphocyte activation in vitro and in vivo.Results Probl Cell Differ.
2006;43:199-218. -
Systemic administration of a TLR7 ligand leads to transient immune incompetence due to peripheral-blood leukocyte depletion.Blood.
2005 Oct 1;106(7):2424-32. Epub 2005 Jun 23. -
Tuning immune responses: diversity and adaptation of the immunological synapse.Nat Rev Immunol.
2005 Jul;5(7):532-45. -
The Mycoplasma-derived macrophage-activating 2-kilodalton lipopeptide triggers global immune activation on nasal mucosa-associated lymphoid tissues.Infect Immun.
2004 Dec;72(12):6978-86. -
A spectrum of biophysical interaction modes between T cells and different antigen-presenting cells during priming in 3-D collagen and in vivo.Blood.
2004 Nov 1;104(9):2801-9. Epub 2004 Jul 15. -
Agonists of proteinase-activated receptor-2 modulate human neutrophil cytokine secretion, expression of cell adhesion molecules, and migration within 3-D collagen lattices.J Leukoc Biol.
2004 Aug;76(2):388-98. Epub 2004 May 20. -
Molecular and functional analysis of Shiga toxin-induced response patterns in human vascular endothelial cells.Blood.
2003 Aug 15;102(4):1323-32. Epub 2003 Apr 17. -
Loss of S100A9 (MRP14) results in reduced interleukin-8-induced CD11b surface expression, a polarized microfilament system, and diminished responsiveness to chemoattractants in vitro.Mol Cell Biol.
2003 Feb;23(3):1034-43. -
Localization of mu-opioid receptor 1A on sensory nerve fibers in human skin.Regul Pept.
2002 Dec 31;110(1):75-83. -
DC–T-cell synapsesTrends Immunol.
2002 Feb 1;23(2):66. -
Two-step negative enrichment of CD4+ and CD8+ T cells from murine spleen via nylon wool adherence and an optimized antibody cocktail.J Immunol Methods.
2001 Dec 1;258(1-2):55-63. -
Dendritic cells and tumor immunity.Semin Immunol.
2001 Oct;13(5):291-302. -
The fate of T cells after conditional ablation of TCR.Trends Immunol.
2001 Oct;22(10):541. -
A holistic view of memory generation: where do T cells reside?Trends Immunol.
2001 May;22(5):240. -
Interaction of T cells with APCs: the serial encounter model.Trends Immunol.
2001 Apr;22(4):187-91. -
Dendritic cells in cancer immunotherapy.Crit Rev Immunol.
2001;21(1-3):133-45. -
Antigen Presentation in Extracellular Matrix: Interactions of T Cells with Dendritic Cells Are Dynamic, Short Lived, and Sequential.Immunity.
2000 Sep;13(3):323-32. -
Evidence for functional relevance of CTLA-4 in ultraviolet-radiation-induced tolerance.J Immunol.
2000 Aug 15;165(4):1824-31. -
Migration of dendritic cells within 3-D collagen lattices is dependent on tissue origin, state of maturation, and matrix structure and is maintained by proinflammatory cytokines.J Leukoc Biol.
2000 May;67(5):622-9. -
T Lymphocytes and Neutrophil Granulocytes Differ in Regulatory Signaling and Migratory Dynamics with Regard to Spontaneous Locomotion and Chemotaxis.Cell Immunol.
2000 Feb 1;199(2):104-14. -
Migration of dendritic cells in 3D-collagen lattices. Visualisation of dynamic interactions with the substratum and the distribution of surface structures via a novel confocal reflection imaging technique.Adv Exp Med Biol.
1997;417:97-103.