Research » Aseptic implant looseningA central problem of modern orthopedics is the limited lifespan of endoprostheses, which seems to be caused by cellular and molecular processes leading to osteolysis around the implant shaft and loosening of the implant and its integrity. We are therefore interested in the interaction of primary human and murine immune cells with metallic and non-metallic wear particles. These processes are visualized and quantified both in vivo and in vitro using 2-Photon intravital microscopy, time lapse microscopy, flow cytometry and lightsheet microscopy. We are aiming at shedding light unto these immunological processes to help develop novel therapies for patients suffering from aseptic implant loosening.
Researchers: Dr. Mike Hasenberg, Dr. Anja Hasenberg, Andreas Kraus